Continued from previous post:

…. the inactivation of influenza virus by ClO2 was caused by oxidation of a tryptophan residue (W153) in hemagglutinin (a spike protein of the virus), thereby abolishing its receptor-binding ability.

In this context it is interesting to remark that the spike protein of the new coronavirus SARS_CoV-2 contains 54 tyrosine, 12 tryptophan, and 40 cysteine residues [29]. If we assume that in an aqueous solution all of these residues are able to react with ClO2 just like the free amino acids, then the inactivation of the viruses can be extremely rapid even in a very dilute (e.g., in a 0.1 mg/L) ClO2 solution.

… an isolated human cell can survive much longer in a ClO2 environment than a planktonic bacterium. Considering that human cells are not isolated but form tissues, their glutathione stock may be many orders of magnitude greater than that of a planktonic bacterium. Additionally, in multicellular organisms circulation transports antioxidants continuously to the cells of the tissue affected by a ClO2 attack, helping them to survive. This strengthens the size-selectivity effect, and explains the surprising observation [15] that ClO2 solutions that are able to kill planktonic bacteria in a fraction of a second may be consumed, because they are safe for humans to drink in a small amount (e.g., drinking 1 L of 24 mg/L ClO2 solution in two portions on a single day caused no observable effects in humans.

https://akjournals.com/view/journals/2060/107/1/article-p1.xml

#chlorinedioxide